Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  10
• Reference
  J:89601 Carpinelli MR, et al., Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6553-8
• ID
  MGI:3575771

Genes

Gene	Assay Type
D10Mit213	PCR
D10Mit214	PCR
Myb	PCR

Notes

• Experiment
  The position of the Myb^Plt4 mutation was mapped using linkage analysis. 65 animals from a (C57BL/6-Myb^Plt4 x 129S1/Sv-Mlp^tm1Wsa)F2 intercross were typed for 148 SSLP markers. Myb^Plt4 mapped between D10Mit213 (11 cM) and D10Mit214 (19 cM).
  
  Linkage between the Myb^Plt3 and Myb^Plt4 mutations was confirmed using 68 animals from a (C57BL/6-Myb^Plt3 x 129S1/Sv-Mlp^tm1Wsa)F1 x 129S1/Sv-Mlp^tm1Wsa backcross. These animals were genotyped for markers closely associated with Myb^Plt4. As suspected the Myb^Plt4 interval showed tight linkage to Myb^Plt3.