Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  7
• Reference
  J:96392 Herron BJ, et al., A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Hum Mol Genet. 2005 Mar 1;14(5):667-77
• ID
  MGI:3574206

Genes

Gene	Assay Type	Description
Ppp1r13l	visible phenotype	Wa3 mutant
D7Mit191
D7Mit57

Notes

• Experiment
  Two mapping crosses were used to map the wa3 phenotype to mouse Chromosome 7. The first used 20 F2 progeny with open eyelids at birth and were obtained from F1 D2/C3H wa3/+ mice. From the initial cross, linkage of wa3 was shown mapping to proximal mouse Chromosome 7. 86 additional homozygous wa3 mice were tested for informative markers spanning chromosome 7. Wa3 mapped between D7Mit191 and D7Mit57. Further molecular analysis showed wa3 as a mutant form of Ppp1r13l.