Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:94605 Cheverud JM, et al., Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes. 2004 Dec;53(12):3328-36
• ID
  MGI:3525649

Genes

Gene	Assay Type
Tgyl1	visible phenotype
D11Mit71	PCR amplified length variant
D11Mit173	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 16 LGXSM (LG=LG/J; SM=SM/J) recombinant inbred (RI) lines to identify QTLs associated with obesity and diabetes traits. Parental strain LG/J exhibits a larger body size compared to parental strain SM/J and these two strains also differ in obesity and diabetes related traits in response to dietary fat. 506 microsatellite markers at an average spacing of 2 to 3 cM were used in the genome scan. 39 loci were mapped but only those reaching genomewide significance are reportedhere.
  
  On mouse Chromosome 11, an interval between D11Mit71 (1.1 cM) and D11Mit173 (17 cM) shows linkage to triglyceride levels on a high fat diet. This locus is named Tgyl1 (triglyceride level 1). SM/J-derived alleles confer increased triglycerides at this locus.