Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:94605 Cheverud JM, et al., Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains. Diabetes. 2004 Dec;53(12):3328-36
• ID
  MGI:3525644

Genes

Gene	Assay Type
Kdnw1	visible phenotype
D5Mit47	PCR amplified length variant
D5Mit353	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 16 LGXSM (LG=LG/J; SM=SM/J) recombinant inbred (RI) lines to identify QTLs associated with obesity and diabetes traits. Parental strain LG/J exhibits a larger body size compared to parental strain SM/J and these two strains also differ in obesity and diabetes related traits in response to dietary fat. 506 microsatellite markers at an average spacing of 2 to 3 cM were used in the genome scan. 39 loci were mapped but only those reaching genomewide significance are reportedhere.
  
  On mouse Chromosome 5, an interval between D5Mit47 (1 cM) and D5Mit353 (24 cM) shows linkage to kidney weight on a high fat diet. This locus is named Kdnw1 (kidney weight 1). SM/J-derived alleles confer increased kidney weight at this locus.