Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:92444 Reilly KM, et al., Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13008-13
• ID
  MGI:3497711

Genes

Gene
D11Mit285
D11Mit271
Nf1
Trp53
Mastr

Notes

• Experiment
  Susceptibility to astrocytoma was investigated in NPcis mice on a C57BL/6J background. NPcix are informative because they carry alleles which modify the effects of mutant Nf1 and Trp53 genes in the development of astrocytoma which is similar to strain 129S4/SvJae. A region between D11Mit271 and D11Mit285 was indicated as including genes which may have a modifying effect on the progression of astrocytoma. SNP analysis showed as many as 41 potential candidate genes within the Mastr region.