Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:93199 Suto J, et al., Confirmation and characterization of murine body weight QTLs, Bwq1 and Bwq2, identified in C57BL/6J x KK-Ay/a F2-Ay/a mice. J Vet Med Sci. 2004 Sep;66(9):1039-45
• ID
  MGI:3487265

Genes

Gene	Assay Type
Zc3h4	visible phenotype
D4Mit111	PCR amplified length variant
D4Mit1	PCR amplified length variant
D4Mit166	PCR amplified length variant

Notes

• Experiment
  95 informative loci were genotyped in a population of 147 (C57BL/6J x KK-A^y)F2 animals to confirm and characterize 2 previously identified body weight QTLs named Bwq1 and Bwq2. Parental strain KK-A^y exhibits increased body weight compared to C57BL/6J, and F2 animals carrying the A^y allele appear to be heavier compared to F2 animals carrying the a allele.
  
  Bwq1 maps to proximal mouse Chromosome 4 and reached a peak LOD score of 5.5 for body weight at 50 days of age at D4Mit111 (21.9 cM). The 95% confidence interval of Bwq1 spans approximately 6.3 cM - 32 cM. The nearest flanking markers are D4Mit1 and D4Mit166. Bwq1 also shows significant linkage to body weight at 40 and 60 days and significant linkage to weight gain at 30-40 days. The KK-derived allele appears to confer increased body weight and weight gain at Bwq1. Other previously identified body weight QTLs mapping near Bwq1 are Bglq4 (6.5 cM) and Wta1 (7 cM).
  
  Bwq2 maps to proximal mouse Chromosome 6 and reached a peak LOD score of 8.8 for body weight at 70 days of age at D6Mit361 (35.2 cM). The 95% confidence interval of Bwq2 spans approximately 29 cM - 47 cM. The nearest flanking markers are D6Mit123 and D6Mit256. Bwq2 also shows significant linkage to body weight at 40, 50, 60, 80, 90, and100 days, and significant linkage to weight gain at 30-40 days. The KK-derived allele confers increased body weight and weight gain at Bwq2 and appears to interact specifically with the A^y allele. Two candidate genes for Bwq2 that are expressed in adipose tissue are Pparg (52.7 cM) and Hrh1 (49 cM). Sequence analysis of Pparg and Hrh1 did not reveal any polymorphisms between C57BL/6J and KK-A^y. Other previously identified body weight QTLs mapping near Bwq2 are Bw18 (35 cM), Obq14 (43.5 cM),Adip2 (46.3cM), and Bgeq4 (46.3 cM).
  
  A suggestive body weight locus mapped to mouse Chromosome 16. This locus is linked to body weight at 40 days (LOD=3.7) and 50 days (LOD=3.3).