Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:86617 Hoebe K, et al., Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat Immunol. 2003 Dec;4(12):1223-9
• ID
  MGI:3055208

Genes

Gene	Assay Type
Ducm1
D7Mit69	PCR amplified length variant

Notes

• Experiment
  57 microsatellite markers were genotyped in a population of (C57BL/6 x 129X1/SvJ)F2 intercross animals to map the gene responsible for dsRNA-induced upregulation of costimulatory molecules (UCM). The segregation pattern of this phenotype follows a 1:3 Mendelian ratio indicating the presence of a single gene locus. This gene is designated Ducm1 (dsRNA-induced UCM 1) and maps to 24.5 cM on mouse Chromosome 7 near D7Mit69 (LOD=5.03).