Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  6
• Reference
  J:78488 Kone J, et al., F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4. Leukemia. 2002 Sep;16(9):1827-34
• ID
  MGI:3054776

Genes

Gene	Assay Type
Fim4	resistance/susceptibility
Lep	reported elsewhere

Notes

• Experiment
  Transgenic animals carrying the SV40 large T antigen under the control of the Cybb promoter on a C57BL/6J background were constructed. Transgenic animals develop histiocytic sarcomas with a latency of 167 days. Injection of the murine Friend leukemia virus was used to accelerate the development of tumors and loci susceptible to viral integration were mapped. Tumor latency in virally infected transgenic animals was on average 103 days.
  
  Virally infected transgenic animals developed myelomonocytic tumors at an incidence of 33% compared to 6% in uninfected transgenic animals. Two virus integration sites were identified, one of which is the previously identified Fli1 at 16 cM on mouse Chromosome 9. The second locus, named Fim4 (Friend MuLV integration site 4), is novel and mapped to mouse Chromosome 6 near the leptin gene (Lep, 10.5 cM). Four proviral insertions were found within a 2 kb region of Fim4 in 3 tumors. Sequence analysis of this region did not identify any obvious candidate genes. The Fim4 locus is syntenic to human Chromosome 7q32. Deletions in the 7q region have been associated with acute myeloid leukemias in humans.