Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:58134 Mayeda AR, et al., A QTL for the genetic variance in free-running period and level of locomotor activity between inbred strains of mice. Behav Genet. 1999 May;29(3):171-6
• ID
  MGI:3053948

Genes

Gene	Assay Type
Cplaq13	visible phenotype
Mtv7	reported elsewhere
D1Mit206	PCR amplified length variant
D1Mit273	PCR amplified length variant
Nhlh1	reported elsewhere
Kcnj10	reported elsewhere
Pou2f1	reported elsewhere
Ddr2	reported elsewhere
Lmx1a	reported elsewhere
Vangl2	reported elsewhere
Atp1b1	reported elsewhere
Rxrg	reported elsewhere

Notes

• Experiment
  The B6.D2-Mtv7^a/J congenic line was used to verify Cplaq3. This congenic carries DBA/2J-derived DNA at the Mtv7 locus (between 89 cM and 106 cM) on a C57BL/6J genetic background. The congenic region includes Cplaq3 (94.2 cM) and contains DBA/2J-derivedDNA from D1Mit206 to D1Mit273. Parental strain C57BL/6J exhibits greater locomotor activity during the circadian period (longer tauDBX) compared to parental strain DBA/2J (shorter tauDBX). The B6.D2-Mtv7^a/J congenic exhibits decreased circadian locomotor activity compared to the background strain C57BL/6J thus confirming the decreasing effect of DBA/2J-derived alleles.
  
  03.11.2015 Curator Note: Because Cplaq3 was originally mapped in J:36675 in 1995 uisng 13 CXB (BALB/cBy x C57BL/6By) recombinant inbred strains, which differ from the congenic mice used here, we consider the currant study a separate mapping experiment and have named the QTL identified Cplaq13.
  
  Candidate genes found near Cplaq3 are Nhlh1, Kcnj10, Pou2f1, Ddr2, Lmx1a, Vangl2, Atp1b1, Mop3, and Rxrg.