Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:88464 Rigby RJ, et al., New loci from New Zealand Black and New Zealand White mice on chromosomes 4 and 12 contribute to lupus-like disease in the context of BALB/c. J Immunol. 2004 Apr 1;172(7):4609-17
• ID
  MGI:3033348

Genes

Gene	Assay Type
Nbwa2	visible phenotype
D4Mit41	PCR

Notes

• Experiment
  (NZW x BALB/c.H2z)F1 x NZB and (NZB x BALB/c)F2 crosses were used to find loci linked to autoantibody production and glomerulonephritis related to lupus-like autoimmune syndrome. Whereas New Zealand Black (NZB) and New Zealand White (NZW) mice are susceptible to a lupus-like autoimmune syndrome. Serological and histological SLE traits showed linkage to regions on mouse Chromosome 12 (Sle14) at D12Mit291 with a LOD greater then 3.6. A region on Mouse chromosome 4 (Nbwa2) at D4Mit41 was linked to total serum IgM (p = 9.6 x 10-3) and IgG (p = 1.1 x 10-3) in the B-F2 cohort at 9.3 and 15.6 cM from the centromere, respectively. Various other novel QTLs were found in mouse Chromosomes 6, 7, 8, 9, and 16.