Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:86415 Rogers MS, et al., Genetic loci that control vascular endothelial growth factor-induced angiogenesis. FASEB J. 2003 Nov;17(14):2112-4
• ID
  MGI:2683515

Genes

Gene	Assay Type
Angvq1	visible phenotype
D10Mit194	PCR amplified length variant
D10Mit42	PCR amplified length variant
P4ha1	reported elsewhere
Col13a1	reported elsewhere
Col6a1	reported elsewhere
Col6a2	reported elsewhere
Col18a1	reported elsewhere
Mmp11	reported elsewhere
Itgb2	reported elsewhere
Tbxa2r	reported elsewhere
Efna2	reported elsewhere
Mif	reported elsewhere
Adora2a	reported elsewhere

Notes

• Experiment
  BXD (C57BL/6J x DBA/2J) RI (recombinant inbred) strains were used to map QTLs associated with vascular endothelial growth factor (VEGF) induced angiogenesis. Parental strain C57BL/6J exhibits lower VEGF responsiveness compared to parental strain DBA/2J (0.8 mm2 vs 1.4 mm2). Angiogenesis was measured by corneal neovascularization assay.
  
  A locus for angiogenesis by VEGF, Angvq1, mapped to mouse Chromosome 10 between D10Mit194 and D10Mit42. Candidate genes mapping to this region are P4ha1, Col13a1, Col6a1,Col6a2, Col18a1, Mmp11, Itgb2, Tbxa2r, Efna2, Mif, and Adora2a. Angvq1 also overlaps with several previously mapped QTLs: Pas11, Bsc1, Igfbp3q2, and Lifespan2.
  
  A second locus named Angvq2 mapped to mouse Chromosome 2 between D2Mit80 and D2Mit82 with strongest association near Il2ra (6.4 cM). Candidate genes mapping to this region are Ptgds, Il1f9, Il1f10, Il1rn, and Edf1. Angvq2 also overlaps with several previously mapped QTLs: Kwq6, Igf1q1, Sluc16, and Sluc22.