Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  15
• Reference
  J:85562 Sedelis M, et al., Chromosomal loci influencing the susceptibility to the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurosci. 2003 Sep 10;23(23):8247-53
• ID
  MGI:2681144

Genes

Gene	Assay Type
Dpml	visible phenotype
D15Mit168	PCR amplified length variant
D15Mit100	PCR amplified length variant
Hsf1	reported elsewhere

Notes

• Experiment
  Genome scan was performed an a population of (C57BL/6J x BALB/cJ)F2 animals to detect loci associated with MPTP-induced dopamine depletion. MPTP is a neurotoxin that causes dopamine loss and Parkinson's disease symptoms in experimental animals. Parental strain C57BL/6J exhibits increased susceptibility to MPTP-induced dopamine depletion compared to BALB/cJ. Interestingly, female F2 animals exhibit a 31.6% mortality rate after MPTP administration whereas male F2 animals exhibit 0% mortality.
  
  Dpml (dopamine loss), a female specific locus mapped to approximately 32.5 cM on mouse Chromosome 15 with LOD=4.8 between 21 cM (D15Mit100) and 44.1 cM (D15Mit68). BALB/cJ-derived alleles confer increased MPTP-induced dopamine depletion at Dpml. A candidate gene mapping to this region is Hsf1.
  
  A suggestive locus mapped to 30 cM (D13Mit91) - 45 cM (D13Mit233) on mouse Chromosome 13. BALB/cJ-derived alleles confer increased MPTP-induced dopamine depletion at this locus.
  
  An interacting locus pair reaching statisticalsignificance was also identified at 29 cM on mouse Chromosome 9 and 79.4 cM on mouse Chromosome 3. Interaction occurs between D9Mit14 and D3Mit147.