Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:78755 Benes H, et al., Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains. J Bone Miner Res. 2000 Apr;15(4):626-33
• ID
  MGI:2662997

Genes

Gene	Assay Type
Sbmd1	visible phenotype
D2Mit312	PCR amplified length variant
D2Mit119	PCR amplified length variant
D2Mit464	PCR amplified length variant
Sbmd2	visible phenotype
D2Mit296	PCR amplified length variant
Col5a1	reported elsewhere
Ptgds	reported elsewhere
Ptgs1	reported elsewhere
Il1rn	reported elsewhere
Il2ra	reported elsewhere
Il15ra	reported elsewhere
Itga6	reported elsewhere
Itga4	reported elsewhere
Itgav	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on two separate intercross populations to identify QTLs associated with bone mineral density. The parental strains studied were AKR/J, SAMR1, and SAMP6. SAMP6 animals exhibit lower bone mineral density compared to SAMR1 andAKR/J animals.
  
  Sbmd1 was identified in the (AKR/J x SAMP6)F2 cross and spans a broad QTL range from 1 cM - 18 cM on mouse Chromosome 2 with a peak LOD score of 4.05. AKR/J-derived alleles confer increased bone density at this locus. Possible candidate genes in the region of Sbmd1 are Col5a1, Ptgs1, Ptdgs, Il1rn, Il2ra, and Il15ra. Sbmd2 was identified in the (SAMR1 x SAMP6)F2 cross and gives a sharp peak at D2Mit296 (18 cM) on chromosome 2 with a LOD score of 3.6. SAMR1-derived alleles confer increased bone mineral density at this locus. Possible candidate genes for Sbmd2 are Itga6, Ptgs1, Itga4, and Itgav. Sbmd1 and Sbmd2 map in close proximity on mouse Chromosome 2 but appear to be separate QTLs. The marker D2Mit296 is shows high significance in both crosses.
  
  Sbmd3 was identified in the (SAMR1 x SAMP6)F2 cross and maps to 11 cM on mouse Chromosome 7. SAMP6-derived alleles confer increased bone mineral density at this locus.
  
  Sbmd4 was identified in the (AKR/J x SAMP6)F2 cross and maps to 49 cM on mouse Chromosome 11 with peak linkage at D11Mit284 (LOD=5.4). SAMP6-derived alleles confer increased bone mineral density at this locus. Candidate genes mapping to the region of Sbmd4 are Vtn, Nog, Pitpn, Csf3, Col1a1, and Cryba1.
  
  The allele effects of these QTLs are mostly additive.