Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:81446 Battersby BJ, et al., Nuclear genetic control of mitochondrial DNA segregation. Nat Genet. 2003 Feb;33(2):183-6
• ID
  MGI:2656786

Genes

Gene	Assay Type
Smdq1	visible phenotype
D5Mit25	PCR amplified length variant

Notes

• Experiment
  Genome scan was performed on a (BALB/c x CAST/Ei)F2 intercross population to identify QTLs affecting mitochondrial DNA (mtDNA) segregation. Three loci were mapped to mouse Chromosomes 2, 5, and 6. Smdq1 maps to 61 cM on mouse Chromosome 5 at D5Mit25 (LOD=31.5) in linkage to mtDNA segregation in the liver at 3 months of age and accounts for 35% of the phenotypic variance. CAST/Ei-derived alleles at Smdq1 appear to influence mtDNA segregation in a dominantly-inherited manner. Smdq2 maps to 51.4 cM on mouse Chromosome 2 at D2Mit480 (LOD=4.0) in linkage to mtDNA segregation in the kidney at 3 months of age and accounts for 16% of the phenotypic variance. CAST/Ei-derived alleles appear to be associated with mtDNA segregation at Smdq2 in a recessive manner. Smdq3 maps to 3.6 cM on mouse Chromosome 6 at D6Mit266 (LOD=4.4) in linkage to mtDNA segregation in the spleen at 12 months of age and accounts for 20% of the phenotypic variance.