Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:79055 Santos J, et al., A new locus for resistance to gamma-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice. Oncogene. 2002 Sep 26;21(43):6680-3
• ID
  MGI:2651493

Genes

Gene	Assay Type
Tlyr1	resistance/susceptibility
D19Mit60	PCR amplified length variant
D19Mit40	PCR amplified length variant
Pdcd4	reported elsewhere
Fas	reported elsewhere
Pten	reported elsewhere

Notes

• Experiment
  C57BL/6J mice develop thymic lymphomas after acute gamma irradiation, whereas Mus spretus and its F1 hybrids with C57BL/6J appear resistant. Genetic analysis using consomic strains between Mus spretus and C57BL/6J indicated that a locus on mouse Chromosome 19 conferred resistance to thymic lymphomas. Further genetic analysis showed that the locus Tlyr1 can be mapped between D19Mit60 and D19Mit40. Homozygosity for C57BL/6J-derived alleles confer resistance to thymic lymphomas at Tlyr1. Candidate genes mapping near Tlyr1 include Pdcd4, Fas and Pten.