Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  2
• Reference
  J:79493 Skinner JA, et al., The imprinted oedematous-small mutation on mouse chromosome 2 identifies new roles for Gnas and Gnasxl in development. Genomics. 2002 Oct;80(4):373-5
• ID
  MGI:2446699

Genes

Gene	Assay Type
D2Ucl1	Content mapping
D2Mit199	Content mapping
Gnas	Content mapping
D2Mit345	Content mapping
D2Mit213	Content mapping
D2Mit210	Content mapping

Notes

• Experiment
  The authors constructed a physcial map in an attempt to fine map the Oed-Sml mutation. Informative clones from the RPCI-23 library provided the following order of markers within 600kb of mouse Chromosome 2: D2Ucl1 - D2Mit199 - Gnas -D2Mit345 - D2Mit213 -D2Mit210. Genetic mapping of this region showed Oed-Sml norecombinatnt with D2Ucl1, D2Mit199, D2Mit213 and D2Mit345. Sequence analysis of Oed mice showed a point mutation in exon 6 of Gnas when compared with non-mutant mice. Therefore the authors suggested that Oed-Sml mutation mapped within the Gnas complex.