Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:76126 Workman MS, et al., Analysis of quantitative trait locus effects on the size and shape of mandibular molars in mice. Genetics. 2002 Apr;160(4):1573-86
• ID
  MGI:2386719

Genes

Gene	Assay Type
Tshp5	visible phenotype
D4Mit17
Tshp6	visible phenotype
D4Mit16

Notes

• Experiment
  76 polymorphic microsatellite markers at an average distance of 27.5 cM were screened in 535 (SM/J x LG/J)F2 animals to identify QTLs associated with tooth development. Parental inbred strain LG/J exhibits larger body size compared to SM/J. Tshp5 and Tshp6, QTLs influencing tooth shape, mapped to mouse Chromosome 4. The Tshp5 interval spans 6.5 cM - 42.5 cM and the Tshp6 interval spans 59.1 cM - 71 cM on chromosome 4. Tshp5 and Tshp6 exceed the P<0.001 significance threshold of LOD=4.185.