Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  3
• Reference
  J:72606 Suzuki T, et al., The gene mutated in cocoa mice, carrying a defect of organelle biogenesis, is a homologue of the human hermansky-pudlak syndrome-3 gene. Genomics. 2001 Nov;78(1/2):30-7
• ID
  MGI:2181576

Genes

Gene	Allele	Assay Type
Hps3	Hps3^coa	visible phenotype
D3Mit91
D3Mit304
D3Mit236
D3Mit165

Notes

• Experiment
  The authors mapped the coa mutation by crossing C57BL/10J mice homozygous for the coa mutation and mice of the PWK strain. Analysis of 2062 backcross progeny placed coa between D3Mit23 and D3Mit223. Genotyping 204 recombinant mice for 21 additional markers in the coa region, narrowed the interval to the region between D3Mit91 proximally and D3Mit204 distally, nonrecombinant with D3Mit236 and D3Mit165. Further physical map construction and sequence analysis showed that the coa phenotype was the result of mutations in the Hps3 gene.