Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:74499 Andrews KL, et al., Quantitative trait loci influence renal disease progression in a mouse model of Alport syndrome. Am J Pathol. 2002 Feb;160(2):721-30
• ID
  MGI:2181047

Genes

Gene	Assay Type
Renf1	visible phenotype
D9Mit12
D9Mit4

Notes

• Experiment
  The Col4a3^tm1Jhm mutation (the mouse model of Alport syndrome) was crossed onto a 129X1/SvJ background and a C57BL/6J background for 6 and 7 generations, respectively. This resulted in mutant lines composed of >98% 129X1/SvJ and >99% C57BL/6J background genetic material. The rate of end-stage renal failure (ESRF) progressed much more quickly in mutant animals on a 129X1/SvJ background (2 months) compared to mutant animals on a C57BL/6J background (> 6 months). Loci responsible for this difference in renal failure progression were mapped in a F1 x C57BL/6J backcross using markers spaced approximately 20 cM apart. Renf1 mapped to mouse Chromosome 9 at approximately 43 cM with a LOD score of 3.26 between D9Mit4 and D9Mit12, and Renf2 mapped to mouse Chromosome 16 at approximately 57 cM with a LOD score of 3.1 at D16Mit153.