Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  15
• Reference
  J:65139 Hoag KA, et al., A quantitative-trait locus controlling peripheral B-cell deficiency maps to mouse Chromosome 15. Immunogenetics. 2000 Sep;51(11):924-9
• ID
  MGI:2158404

Genes

Gene	Assay Type
Tnfrsf13c	visible phenotype
D15Mit211
D15Mit29
D15Mit118
D15Mit76

Notes

• Experiment
  Linkage analysis was performed on a population of (A/WySnJ x CAST/Ei)F2 animals to detect loci involved in peripheral B-lymphocyte homeostasis. Parental strain A/WySnJ exhibits rapid apoptosis of peripheral B-lyphocytes whereas CAST/Ei does not. A significant locus named Bcmd (B-cell maturation defect) mapped to mouse Chromosome 15 from 30 cM - 53 cM with a LOD score >17. A possible candidate gene for Tnfrsf13c is Csf2rb2. Regions of synteny to human chromosomes for Tnfrsf13c are human Chromosome 8q21, 8q24, 22q12, and 22q13.