Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  15
• Reference
  J:72440 Newton JM, et al., Mutations in the Human Orthologue of the Mouse underwhite Gene (uw) Underlie a New Form of Oculocutaneous Albinism, OCA4. Am J Hum Genet. 2001 Nov;69(5):981-8
• ID
  MGI:2155589

Genes

Gene	Allele	Assay Type
Ghr
D15Mit12
Slc1a3
D15Mit175
D15Mit80
D15Mit224
D15Mit10
Slc45a2	Slc45a2^Uw-dbr	visible phenotype
D15Mit177
D15Mit179
D15Mit53
D15Mit199
D15Mit81
D15Mit266
D15Mit9
Myo10

Notes

• Experiment
  Analysis of F2 offspring derived from the [C57BL/6J-Uw^dbr/Uw^dbr X CAST/Ei-+/+] bracketed the uw locus between Ghr and Myo10 on proximal chromosome 15 with the order of markers being : Ghr - D15Mit12 - Slc1a3 - D15Mit80, D15Mit175, D15Mit224 - D15Mit10 - Matp^uw-dbr, D15Mit177 - D15Mit179 - D15Mit53, D15Mit199 - D15Mit81, D15Mit266a - D15Mit9, Myo10. Analysis of gene/EST data in the region using the comparative map of the region in human identified an EST cluster with expression restricted to melanocytes. Subsequent analysis of the transcript derived from this cluster showed mutations in different alleles of uw. Mutations leading to oculocutaneous albinism were also identified in human orthog of the uw gene.