Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:70379 Cohen RM, et al., Quantitative trait loci affecting the behavior of A/J and CBA/J intercross mice in the elevated plus maze. Mamm Genome. 2001 Jul;12(7):501-7
• ID
  MGI:2151845

Genes

Gene	Assay Type	Description
Elmaz1	other	behavioral
D5Mit20
D5Mit405
Elmaz2	other	behavioral
D5Mit138
D5Mit101
Pde6b	reported elsewhere
D5Mit239
D5Mit31

Notes

• Experiment
  A (A/J-Tyr^c/Tyr^c x CBA/J-Pdeb^rdl/Pdeb^rdl)F2 intercross was used to map QTLs associated with elevated plus maze behavior. Parental strain A/J-Tyr^c/Tyr^c is albino with a mutation in the tyrosinase gene and exhibits strong preference for closed arm entry of the maze. Parental strain CBA/J-Pdeb^rdl/Pdeb^rdl is mutant for the Pde6b gene and exhibits a weak preference for open arm entry of the maze. Two loci on mouse Chromosome 5, Elmaz1 and Elmaz2, are linked to open arm entry at 52 cM - 63 cM (LOD=1 6.4 between D5Mit20 and D5Mit405) and at 69 cM - 81 cM (LOD = 30.9 between D5Mit138 and D5Mit101), respectively. Pde6b maps to the first Chromosome 5 interval and is a strong candidate gene for Elmaz1. There is also evidence of linkage of closed armmaze entry with the Tyr gene on mouse Chromosome 7 at 44 cM.