Experiment
188 (SMXA24 x A/J)F1 x A/J backcross animals were typed for 75 microsatellite markers to detect loci associated with resistance to urethan-induced pulmonary adenomas. SMXA24 is a recombinant inbred (RI) strain derived from progenitor strains SM/J and A/J. SMXA24 is resistant to pulmonary adenomas as is progenitor strain SM/J. Progenitor strain A/J is susceptible to pulmonary adenomas. Linkage analysis detect 2 loci associated with resistance to pulmonary adenomas on mouse Chromosomes 11 and 12 and are said to be identical to previously identified QTLs Par1 and Par3, respectively (Manenti et al, J:32079). In this study, Par1 gave a LOD score of 4.35 at D11Mit70 and Par3 gave a LOD score of 6.47 at D12Mit5. SM/J-derived alleles confer dominant resistance to pulmonary adenomas at Par1 and Par3. A possible candidate gene for Par3 is protein kinase C, eta (Prkch). Par1 and Par3 regions of synteny at 17q11-q23 and 14q11-q24, respectively, appear to be associated with loss of heterozygosity in human lung cancer.
02.05.2016 Curator Note: Because Par1 was originally mapped in J:32079 using an (A/J x M. spretus) x C57BL/6J interspecific backcross, which differs from the mapping population used here, we have equated this QTL with Par8 which was mapped in an identical population in J:41849.
Analysis Tools