Experiment
Genome scan was performed on animals from a (C57BL/6J x DBA/2J)F2 intercross to identify QTLs associated with tail length and age-related body weight, and test concordance with QTLs mapped in a previous study. DBA/2J animals are heavier than C57BL/6J animals. Five out of 11 previously mapped QTLs were detected. QTLs for body weight at 3 weeks of age mapped to mouse Chromosome 4 from 40 cM - 60 cM (Bwtq2, LOD = 4.4 at 55 cM), mouse Chromosome 9 from 0 cM - 50 cM (Bwtq4, LOD = 8.3 at 8 cM), and mouse Chromosome 11 from 20 cM - 55 cM (Bwtq5, LOD = 9.5 at 27.8 cM). QTLs for body weight at 10 weeks of age mapped to mouse Chromosome 1 from 40 cM - 70 cM (Bwtq1, LOD = 8.8 at 54.3 cM), mouse Chromosome 6 from 0 cM - 29 cM (Bwtq3, LOD = 4.4 at 4 cM), and mouse Chromosome 15 from 25 cM - 50 cM (Bwtq6, LOD = 7.6 at 41.2 cM). A major QTL for tail length mapped to mouse Chromosome 1 from 40 cM - 70 cM (Tlln, LOD = 33 at 50 cM).