Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:52572 Encinas JA, et al., QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2. Nat Genet. 1999 Feb;21(2):158-60
• ID
  MGI:2149613

Genes

Gene	Assay Type
Idd3	resistance/susceptibility
Il2	reported elsewhere
D3Nds36
D3Nds34
Fgf2	reported elsewhere

Notes

• Experiment
  A locus for experimental autoimmune encephalomyelitis (EAE) resistance colocalizes with a locus for diabetes resistance, Idd3, to a 0.15 cM interval on mouse chromosome 3 at approximately 19.2 cM. NOD congenic lines were constructed carrying C57BL/6-derived (resistant) alleles on a NOD (susceptible) background at Idd3 (NOD.B6-Idd3 line) and at Idd17, Idd10, and Idd18 (NOD.B6-Idd17, Idd10, Idd18 line). NOD.B6-Idd3 animals carry C57BL/6-derived alleles from D3Nds36 to D3Nds34 and are resistant to diabetes and exhibit mild EAE symptoms. NOD.B6-Idd17, Idd10, Idd18 animals carry C57BL/6-derived alleles from D3Mit51 to D3Mit124 and are susceptible to both diabetes and EAE. The 0.15 cM NOD.B6-Idd3 interval contains Il2 (interleukin 2), a candidate gene for bothdiseases. Investigation of Il2 revealed differences in the sequence and glycosylation status of Il2 between C57BL/6 and NOD strains.