Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:45962 Sebastiani G, et al., Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in wild-derived mice. Genomics. 1998 Jan 15;47(2):180-6
• ID
  MGI:2137739

Genes

Gene	Assay Type
Slc11a1	visible phenotype
Ity3	visible phenotype
D1Mcg4
D1Mit100

Notes

• Experiment
  191 animals from a (C57BL/6J x MOLF/Ei)F2 cross were typed for 115 markers to identify QTLs involved in resistance to Salmonella typhimurium infection. While parental C57BL/6J and MOLF/Ei strains are susceptible to infection by S.typhimurium, segregationof resistance alleles at Nramp1 and Lps in the MOLF/Ei strain confers a resistant phenotype to F2 progeny. Three significant QTLs were mapped in this study: Ity1 (LOD=18.8 at D1Mcg4 spanning 21.6cM-54.4cM) and Ity3 (LOD=4.8 at D1Mit100 spanning 59.7cM-87.7cM) on chromosome 1, and Ity2 (LOD=7.0 at D11Mit5 spanning 27cM-49cM) on chromosome 11. Ity1 confers dominantly inherited resistance to infection by S.typhimurium and is in linkage (within 6kb) to Nramp1, while Ity3 confers recessively inherited susceptibility. The Ity1 QTL most likely represents mouse Slc11a1. The Ity2 locus has an additive effect and confers a resistant phenotype. Ity2 was analyzed for interaction with Nramp1 and no interaction was detected. Three suggestive QTLs were also identifiedon chromosomes 6, 10, and 13. The resistance locus on chromosome 6 (LOD=3.6 at D6Mit9) appears to have an additive effect, while the susceptibility loci on chromosomes 10 (LOD=3.1 at D10Mit91) and 13 (LOD=2.4 at D13Mit117) are recessively inherited.