Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  14
• Reference
  J:68417 Hitzemann R, et al., Effect of genetic cross on the detection of quantitative trait loci and a novel approach to mapping QTLs. Pharmacol Biochem Behav. 2000 Dec;67(4):767-72
• ID
  MGI:2137487

Genes

Gene
Hpic3
Hpic4

Notes

• Experiment
  The authors use a novel approach in mapping QTLs involved in murine behavioral phenotypes. A genome wide scan was performed with (C57BL/6J x DBA/2J)F2 and (BALB/cJ x LP/J)F2 intercrosses crosses to map QTLs affecting in three different behavioral phenotypes. The strains chosen have widely differing polymorphisms and phenotypes and the QTLs identified from each cross do not appear to have overlap. Two significant QTLs (LOD>4.3 threshold), Hpic3 and Hpic4, for haloperidol-induced catalepsy mapped to 0 - 20 cM and 35 - 60 cM on mouse Chromosome 14, respectively. Both QTLs, Hpic3 and Hpic4, were identified from the (BALB/cJ x LP/J)F2 intercross. The authors also used a subtractive method to resolve a broad QTL (60-100 cM) for basal activity on distal Chromosome 1. Genotyping information from (C57BL/6J x DBA/2J)F2, (C57BL/6J x A/J)F2, and (C57BL/6J x BALB/cJ)F2 intercrosses was used to screen 254 microsatellite markers across the locus. Only markers polymorphic between all four strains (35 markers) were further analyzed. These highly informative markers revealed 2 separate QTLs: one previously reported by Talbot for basal activity at 67 cM and another at 95 - 105 cM.