Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:66233 Brockmann GA, et al., Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000 Dec;10(12):1941-57
• ID
  MGI:1931505

Genes

Gene	Assay Type
Afpq7	visible phenotype
Afw12	visible phenotype

Notes

• Experiment
  QTL effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i xDBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan. Locations of the QTL were provided by the authors and may not be equivalent to the closest microsatellites. Abdominal fat percent QTL 1 was mapped to mouse Chromosome 3 with a cM range from 23 to 37 cM. Abdominal fat weight QTL was mapped to mouse Chromosome 3 position 30 with a range from 23 to 36 cM.
  
  10.03.2014 - Curator Note: We had originally associated the abdominal fat weight QTL identified here, mapping to 30 cM between 23 and 36cM on mouse Chr 3, as Afw1. Afw1 was originally mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578 in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Afw12.
  
  04.14.2015 - Curator Note: The abdominal fat percent QTL 1 (Afpq1) was originally mapped in J:49578 in 1998 using DU6 (selected for high body weight) and a DUKs female mice, which differ from the cross used here. We consider the current mapping study a separate mapping experiment and have named the QTL identified here mapping to mouse Chromosome 3 with a cM range from 23 to 37 cM as Apfq7.