CROSS Mapping MGI Mouse MGI:1890214

Mapping Data

Experiment

CROSS
Chromosome

13
Reference

J:64163 Growney JD, et al., High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis. Genome Res. 2000 Aug;10(8):1158-71
ID

MGI:1890214

Experiment

The authors used physical maps of the Lgn1 region to demonstrate that the Birc1 gene array differ in the structure and number of subunit genes. central amplification within the Birc1 array is larger in the 129 strains than in A/J and C57BL/6J. However, the fact that a Legionella pneumophila permissive strain (A/J) and a Legionella pneumophila restrictive strain (C57BL/6J) have similar gene rearrangements and copy numbers , indicated that differencez in the Birc1 gene number were not responsible for the Lgn1 phenotype. The completed physical map of the region was used to finely map the recombination breakpoints across the Lgn1 interval in animals derived from a (A/J x C57BL/6J) backcross. The new critical interval for Lgn1 is restricted to the region between D13Die6 to D13Die30c and contains only the Birc1b, Birc1e and the 3' portion of the Birc1c-ps3 genes.

Type

Backcross, sexes unspecified or combined
Female Parent

<a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a>/
Strain

(A/J x C57BL/6J)F1
Male Parent

<a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a>/<a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a> <a>
Strain

A/J
Allele 1

a from Not Specified
Allele 2

a from C57BL/6J

CROSS Data

MC #mice	D13Die6	D13Die26	D13Die37	D13Die24	D13Die27	D13Die35b	D13Die25a	Naip5	D13Die7b	D13Die36a	D13Die30c	D13Die35a	D13Die25b	D13Die7a	D13Die36b	D13Die3
3	b	b	b	b	b	b	b	b	b	b	b	b	b	b	b	b
2	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a
2	b	b	a	a	a	a	a	a	a	a	a	a	a	a	a	a
1	a	a	b	b	b	b	b	b	b	b	b	b	b	b	b	b
2	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a

MC #mice	D13Die6	D13Die26	D13Die37	D13Die24	D13Die27	D13Die35b	D13Die25a	Naip5	D13Die7b	D13Die36a	D13Die30c	D13Die35a	D13Die25b	D13Die7a	D13Die36b	D13Die3
3	b	b	b	b	b	b	b	b	b	b	b	b	b	b	b	b
2	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a
2	b	b	a	a	a	a	a	a	a	a	a	a	a	a	a	a
1	a	a	b	b	b	b	b	b	b	b	b	b	b	b	b	b
2	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MC #mice	D13Die6	D13Die26	D13Die37	D13Die24	D13Die27	D13Die35b	D13Die25a	Naip5	D13Die7b	D13Die36a	D13Die30c	D13Die35a	D13Die25b	D13Die7a	D13Die36b	D13Die3
3	b	b	b	b	b	b	b	b	b	b	b	b	b	b	b	b
2	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a
2	b	b	a	a	a	a	a	a	a	a	a	a	a	a	a	a
1	a	a	b	b	b	b	b	b	b	b	b	b	b	b	b	b
2	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a

MC #mice	D13Die6	D13Die26	D13Die37	D13Die24	D13Die27	D13Die35b	D13Die25a	Naip5	D13Die7b	D13Die36a	D13Die30c	D13Die35a	D13Die25b	D13Die7a	D13Die36b	D13Die3
3	b	b	b	b	b	b	b	b	b	b	b	b	b	b	b	b
2	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a
2	b	b	a	a	a	a	a	a	a	a	a	a	a	a	a	a
1	a	a	b	b	b	b	b	b	b	b	b	b	b	b	b	b
2	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a	a