Mapping Data

Experiment

• Experiment
  TEXT-Radiation Hybrid
• Chromosome
  14
• Reference
  J:60133 Engert JC, et al., ARSACS, a spastic ataxia common in northeastern Quebec, is caused by mutations in a new gene encoding an 11.5-kb ORF. Nat Genet. 2000 Feb;24(2):120-5
• ID
  MGI:1354904

Genes

Gene	Assay Type
Sacs	PCR amplified length variant, direct sequencing
D14Mit37
D14Mit66

Notes

• Experiment
  Authors isolated a BAC clone using mouse ESTs with similarity to the human SACS gene. Sequence analysis confirmed that the genomic clone contained the mouse ortholog of SACS. The mouse Sacs gene was mapped to Chromosome 1, near D1Mit373 (lod score of 25.) using the mouse-hamster T31 Radiation Hybrid panel. Subsequently Dr. Engert was to show that Sacs mapped with makers on mouse Chromosome 14 and not Chromosome 1.