Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:56630 Ferraro TN, et al., Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice. J Neurosci. 1999 Aug 15;19(16):6733-9
• ID
  MGI:1345829

Genes

Gene	Assay Type
D5Mit398
Szs6	resistance/susceptibility

Notes

• Experiment
  DBA/2J and C57BL/6J mice exhibit differential sensitivity to seizure induced by pentylenetetrazol (PTZ) with DBA/2J mice being sensitive and C57BL/6J mice being relatively resistant. PTZ-induced seizure responses were studied in DBA/2J, C57BL/6J, (DBA/2Jx C57BL/6J)F1 and (DBA/2J x C57BL/6J)F2 intercross mice. QTL mapping and complementary statistical analysis identified a locus on Chromosome 5 near D5Mit398 (LOD = 4.18 with 5.8% of total variance explained). Relevant candidate genes near this locus include Gabra2 and Gabra1. Szs6 is derived from a C57BL/6J-derived susceptibility allele.