Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  X
• Reference
  J:56501 Suto J, et al., Genetic analysis of neonatal death with growth retardation in F(1) male Dh/+ mice. Mamm Genome. 1999 Aug;10(8):777-83
• ID
  MGI:1343414

Genes

Gene	Assay Type
DXMit135
DXMit157
Grdhq1	visible phenotype

Notes

• Experiment
  The authors generated 394 live-born pups from the [(DDD x DH- +/+)F1 x DH- Dh/+] backcross. Of the 92 Dh/+ maes, 42 exhibited growth retardation. These animals were genotyped for 90 autosomal and 7 X Chromosomal microsatellite loci to identify the putative genetic loci in the DDD genome that causes abnormalities in the presence of the Dh allele. A statistically significant evidence for linkage was identified on the distal edge of the X Chromosome near DXMit135 (chi square >48.00, P = 6.7 e-13) and DXMit157 (chi square >48.00, P = 3.4 e-12). In 42 growth retarded Dh/+ males, 34 had the X Chromosome from DDD mice and 8 had the X Chromosome from DH mice. In contrast in 48 normally weaned Dh/+ males, only 3 had the X Chromosome from DH at DXMit135. The causal locus has been assigned the symbol Grdhq1.