Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  4
• Reference
  J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
• ID
  MGI:1342508

Genes

Gene	Assay Type
D4Mcg10	PCR amplified length variant
D4Nds9	PCR amplified length variant
Tlr4	visible phenotype
D4Mcg5	PCR amplified length variant
D4Mit178	PCR amplified length variant
D4Mcg24	PCR amplified length variant
D4Mcg25	PCR amplified length variant
D4Mcg27	PCR amplified length variant

Notes

• Experiment
  A group of 597 (DBA/2J x C3H/HeJ)F1 x C3H/HeJ and 748 (C57BL/6J)F1 x C3H/HeJ backcross progeny showed no recombination between the Lps phenotype (currently associated with marker Tlr4) and markers D4Mcg24, D4Mcg25, D4Mcg27. D4Mcg10 mapped 0.3 cM centromeric to D4Nds9 and D4Mcg5 cosegregated with the distal flanking markers D4Mit178. The Lps phenotype region was thus confined to a genetic interval of 0.9 cM.