Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  3
• Reference
  J:53340 Sprunger LK, et al., Dystonia associated with mutation of the neuronal sodium channel Scn8a and identification of the modifier locus Scnm1 on mouse chromosome 3. Hum Mol Genet. 1999 Mar;8(3):471-9
• ID
  MGI:1341404

Genes

Gene	Assay Type
Scnm1	visible phenotype
D3Mit6

Notes

• Experiment
  A set of (C57BL/6J-Scn8a^med-J/+ x C3H)F2 animals (demonstrating a paralyzed phenotype; 20 demonstrating a dystonic phenotype) were analyzed for 62 microsatellite markers from 20 Chromosomes. A deficiency of the C57BL/6J allele at marker D3Mit6 in the dystonic pool and a deficieny of the C3H allele in the paralyzed pool was demonstrated. The data suggested to the authors that a modifier gene responsible for the phenotypic difference is present on mouse Chromosome 3.