Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:52119 Kosarova M, et al., The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively. Immunogenetics. 1999 Feb;49(2):134-41
• ID
  MGI:1333954

Genes

Gene	Assay Type
D5Mit63
Cora1	visible phenotype

Notes

• Experiment
  The strains BALB/cHeA and STS/A differ in the production of Il4 and Il10 after stimulation with concanavalin A (ConA). The genetic basis of this difference was analyzed using the recombinant congenic (RC) strains of the BALB/c - c - STS/Dem (CcS/Dem) series. The authors analyzed correlation between expression of Il4 and Il10 in 80 (CcS-20 x BALB/c)F2 hybrids after stimulation with ConA at a novel QTL, Cora1, marked by D5Mit63 on mouse Chromosome 5. Higher correlation was observed in homozygotes in either the BALB/c or STS/A allele than in heterozygotes (P = 0.0448).