Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:41849 Pataer A, et al., Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred mouse strains. Cancer Res. 1997 Jul 15;57(14):2904-8
• ID
  MGI:1327570

Genes

Gene	Assay Type
D12Mit37	PCR amplified length variant
Par3	visible phenotype
D12Mit5	PCR amplified length variant
D12Mit17	PCR amplified length variant

Notes

• Experiment
  Unlike A/J, SM/J mice rarely develope spontaneous pulmonary adenomas (PA) and are resistant to PA induction by carcinogens. The incidence of PA in 20 SMXA RI strains was first examined. SMXA24 was highly resistant to PA despite having A/J derived alleles at all 4 susceptible Pas regions, Pas1-4.
  
  Results from 188 (SMXA24 x A/J)F1 x A/J and A/J x (SMXA24 x A/J)F1 backcrossed mice were pooled and analyzed. Linkage analysis reveal two QTL.
  
  A resistant QTL mapped to Chr 11 between markers D11Mit14 and D11Mit70 with a LOD score of 4.35, p=0.0012, accounting for 10.2% of the trait variance. Authors speculate that the QTL may be the previously identified Par1 QTL becuase of its proximity.
  
  02.04.2016 Curator Note: Because Par1 was originally mapped in J:32079 using an (A/J x M. spretus) x C57BL/6J interspecific backcross, which differs from the mapping population used here, we consider the current study a separate experiment and have named the the QTL Par8.
  
  Another resistance QTL mapped to Chr 12 with marker a LOD score of 6.47 at marker D12Mit5, p=0.00015. This locus accounted for 14.7% of the trait varaince and was designated Par3, pulmonary adenoma resistance 3.
  
  SM/J derived alleles effectively reduced the number of pulmonary adenomas at each locus.