Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:44650 Gershenfeld HK, et al., Mapping quantitative trait loci for fear-like behaviors in mice. Genomics. 1997 Nov 15;46(1):1-8
• ID
  MGI:1316450

Genes

Gene	Assay Type
Exq2	visible phenotype
Exq3	visible phenotype
D1Mit445	PCR amplified length variant
D1Mit435	PCR amplified length variant

Notes

• Experiment
  Parental strains (A/J x C57BL/6J) and their F1 and 518 F2 intercross offspring were assessed for their fear-like behaviors in open field behavior tests. Parental strain C57BL/6J exhibits increased light-dark transitions and increased center time in an open field compared to parental strain A/J. Whole genome scan using 114 polymorphic markers indicated the presence of 2 distinct non-overlapping quantitative trait loci (QTLs) on mouse Chromosome 1 at 70 cM (Exq2, LOD = 7.7 at D1Mit445) and at 37 cM (Exq3, LOD = 3.97 at D1Mit435). Exq2 is linked to initial center time in an open field and Exq3 is linked to trial 1 average center time in an open field.
  
  A suggestive locus mapped to 49 cM on mouse Chromosome X with LOD = 2.84 at DXMit172. This locus is associated with LD transitions during the third LD transition trial (LD3) but not the first or second.