Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:49054 Butterfield RJ, et al., New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J Immunol. 1998 Aug 15;161(4):1860-7
• ID
  MGI:1309751

Genes

Gene	Assay Type
Eae44	visible phenotype
D11Mit2	PCR amplified length variant
D11Mit307	PCR amplified length variant
D11Mit53	PCR amplified length variant
Eae7	visible phenotype
D11Bhm149	PCR amplified length variant
D11Mit330	PCR amplified length variant
D11Mit285	PCR amplified length variant

Notes

• Experiment
  Authors isolated quantitative trait loci believed to be invloved with the disease frequency of experimental allergic encephalomyelitis (EAE). (SJL/J x B10.S/DvTe)F2; SJL/J (susceptible) and B10.S/DvTe (resistant) mice; were bred to create F2 progeny used in the analysis.
  
  A genome wide scan of 291 affected and 390 unaffected animals indicated the presence of 2 loci mapping approximately 30 cM apart on mouse Chromosome 11, named Eae6 and Eae7 by the authors.
  
  6.29.2015 Curator Note: Eae6 was originally mapped using a (ABH x NOD)F1 x NOD backcross in J:29171 in 1995; a cross which differs from the cross used here. We consider this a separate mapping experiment and have named the QTL identified on Chr 11, Eae44.
  
  Eae44 mapped between flanking markers D11Mit2 and D11Mit307 with a peak LOD score of 4.51 at D11Mit53.
  
  Eae7 mapped between flanking markers D11Bhm149 and D11Mit330 with a peak LOD score of 4.05 at D11Mit285.