Mapping Data

Experiment

• Experiment
  TEXT-Cytogenetic Localization
• Chromosome
  5
• Reference
  J:46979 Beru N, et al., Activation of the erythropoietin gene due to the proximity of an expressed gene. DNA. 1989 May;8(4):253-9
• ID
  MGI:1202786

Genes

Gene	Assay Type	Description
Gnb2	direct sequencing	Rearranged Epo genomic 1
Epo	direct sequencing	Rearranged Epo genomic 1

Notes

• Experiment
  The IW32 erythroleukemic cell line was developed from the spleens of mice infected with FMuLv. Both a normal Epo locus and a rearranged Epo locus/allele have been isolated from this strain. While coding and 3' flanking sequences for both alleles of Epo appear identical, differences can be found in their 5' flanking regions. The rearranged allele is consitutively expressed, perhaps due to the localization of the transcriptionally active gene in opposite orientation, approximately 1kb distant. This active locus was later identified as Gnb2 (J43802).