Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  4
• Reference
  J:43429 Cox GA, et al., Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997 Oct 3;91(1):139-48
• ID
  MGI:1196918

Genes

Gene	Allele	Assay Type	Description
D4Mit16		reported elsewhere
D4Mit203		reported elsewhere
Sdc3		SSCP	SyndF, SyndR
D4Mit309		reported elsewhere
D4Mit71		reported elsewhere
D4Mit204		reported elsewhere
Slc9a1	Slc9a1^swe	PCR amplified length variant	mNhe1pro-F, mNhe1pro-R and JS167, JS135
D4Mit339		reported elsewhere
Htr1d		SSCP	3F, 3R
Htr6		SSCP	5Htr6-pA, 5Htr6-pB
D4Mit68		reported elsewhere

Notes

• Experiment
  The swe (slow-wave epilepsy) allele was mapped to Slc9a1 by phenotypic and various PCR methods. The authors analyzed 602 (SJL/J-swe x C57BL/6J)F2 progeny and determined the following order of loci on mouse Chromosome 4: D4Mit16 - 0.77 +/- 0.29 cM - D4Mit203 - Synd3 - 1.43 +/- 0.39 cM - D4Mit309 - 0.98 +/- 0.25 cM - D4Mit71 - D4Mit204 - Slc9a1^swe - 0.06 +/- 0.07 cM - D4Mit339 - 0.80 +/- 0.32 cM - Htr1d - Htr6 - 0.66 +/- 0.30 cM - D4Mit68. Authors also analyzed 161 (SJL/J-swe x B6.SPRET-distal Chr 4)F2 mice to confirm linkage of the swe phenotype to Chromosome 4 markers. The swe phenotype did not recombine with Slc9a1 in 1526 meioses.