Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  11
• Reference
  J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
• ID
  MGI:1195138

Genes

Gene	Allele	Assay Type
D11Mit65		overlapping clones
D11Nds1		overlapping clones
Rpa1		overlapping clones
D11Rub2		overlapping clones
D11Rub3		overlapping clones
D11Rub4		overlapping clones
Prpf8		overlapping clones
D11Rub5		overlapping clones
D11Rub6		overlapping clones
D11Rub7		overlapping clones
Cox7c		overlapping clones
Pitpna	Pitpna^vb	overlapping clones
Inpp5k		overlapping clones
Myo1c		overlapping clones
D11Rub8		overlapping clones
D11Rub9		overlapping clones
Crk		overlapping clones
D11Rub10		overlapping clones
D11Rub11		overlapping clones
D11Rub12		overlapping clones
Ywhae		overlapping clones
D11Rub13		overlapping clones
D11Rub14		overlapping clones
D11Rub15		overlapping clones
D11Rub16		overlapping clones
D11Rub17		overlapping clones
D11Mit7		overlapping clones
D11Mit245		overlapping clones

Notes

• Experiment
  YAC and P1 clones covering the vibrator mutation region of mouse Chromosome 11 were physically mapped. The order of loci in the region was reported as: D11Mit65 - D11Nds1 - Rpa1 - D11Rub2 - D11Rub3 - D11Rub4 - Prpf8 - D11Rub5 - D11Rub6 - D11Rub7 - Cox7c - Pitpna^vb - Pps - Myo1c - D11Rub8 - D11Rub9 - Crk - D11Rub10 - D11Rub11 - D11Rub12 - Ywhae - D11Rub13 - D11Rub14 - D11Rub15 - D11Rub16 - D11Mit7 - D11Mit245. Sequence of a vibrator mouse clone (clone 4232) found to be completely complement the mutationin transgenic studies revealed the presence of a ~6kb intracisternal A particle (IAP) element in the intron 4 sequence of Pitpn. This sequence was not found in the wildtype DBA/2J progenitor strain. PCR analysis showed that this insertion is recombinationally inseperable from vb.