About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Nat8f5b2b1702.1Clo
Name: N-acetyltransferase 8 (GCN5-related) family member 5; Bench to Bassinet Program (B2B/CVDC), mutation 1702, subline 1 Cecilia Lo
MGI ID: MGI:5696519
Synonyms: TLC
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 1702-003-2 (E16.5) displays malaligned great arteries indicative of double outlet right ventricle (DORV) as confirmed by ECM imaging.b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
EFIC Summaryb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Serial 2D EFIC image stack in the coronal plane of 1702-003-2 (E16.5) reveals double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), biventricular hypertrophy, and coronary fistula.
Click thumbnail to play movie.		b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Mutant 1702-003-2 (E 16.5) displays abnormal lung lobation (2 lobes on right/1 lobe on left).b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Mutant 1702-003-2 (E 16.5) exhibits an omphalocoele and severe hydropsb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Mutant 1702-003-1 (E16.5) shows malaligned great arteries which is diagnosed as double outlet right ventricle by ECM imaging.b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
EFIC Summaryb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Serial 2D EFIC image stack in the coronal plane of 1702-003-1 (E16.5) reveals double outlet right ventricle with subaortic VSD {S,D,D}.
Click thumbnail to play movie.		b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Color flow spectral Doppler imaging of mutant 1702-003-1 in the frontal view shows both the aorta and pulmonary artery originating from the RV, with subaortic VSD and muscular VSD, indicating DORVb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Mutant 1702-003-3 (E 16.5) exhibits heterotaxy with mesocardia.b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
EFIC Summaryb2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Serial 2D EFIC image stack in the coronal plane of 1702-003-3 (E16.5) reveals muscular VSD
Click thumbnail to play movie.		b2b1702Clo/b2b1702CloC57BL/6J-b2b1702Clo
Nat8f5b2b1702.1Clo/Nat8f5b2b1702.1CloC57BL/6J-Nat8f5b2b1702.1Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory