Phenotype Images associated with this Allele
|
Nomenclature
|
|
Symbol:
|
b2b3077.2Clo
|
|
Name:
|
Mutant line 3077, subline 2 Cecilia Lo;
Bench to Bassinet Program (B2B/CVDC), mutation 3077, subline 2 Cecilia Lo
|
|
MGI ID:
|
MGI:5646614
|
|
Synonyms:
|
Po
|
|
Images for
Allele
|
Click images for details
 | Mutant 3077-006-4 (E15.5) exhibits aortic atresia with accessory anterior lung lobes, hypoplastic left atrium, and thickened left ventricle wall. This is diagnosed as aortic atresia, left venricle hypertrophy, and hypoplastic left heart syndrome (HLHS) spectrum heart by ECM histopathology. | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
 | EFIC Summary | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
 | Serial 2D ECM image stack of 3077-006-4 (E15.5) in the coronal plane reveals hypoplastic left heart syndrome with aortic atresia, mitral valve stenosis, and muscle bound hypoplastic left ventricle. Also noted was abnormal acccessory anterior lung lobes.
Click thumbnail to play movie. | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
 | 3D ECM reconstruction of 3077-006-4 shows accessory anterior lung lobes positioned above the atria.
Click thumbnail to play movie. | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
 | Mutant 3077-006-4 (E15.5) presents with hydrops, short snout, micrognathia, short limbs, clubbed feet, syndactyly, and short tail. | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
 | Mutant 3077-006-4 (E15.5) presents with a cleft lip. | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
 | Mutant 3077-006-4 (E15.5) exhibits a cleft palate. | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
 | Mutant 3077-006-4 (E15.5) shows a short gut. | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
 | Mutant 3077-006-4 (E15.5) exhibits abnormally placed adrenal glands and cystic kidneys, later confirmed showing a few glomerular cysts by histopathology. | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
 | Mutant 3077-006-4 (E15.5) shows some glomerular cysts. | b2b3077Clo/b2b3077Clo | C57BL/6J-b2b3077Clo | | b2b3077.2Clo/b2b3077.2Clo | C57BL/6J-b2b3077.2Clo |
|
Analysis Tools