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Phenotype Images associated with this Allele
Nomenclature
Symbol: b2b3077Clo
Name: Mutant line 3077 Cecilia Lo; Bench to Bassinet Program (B2B/CVDC), mutation 3077 Cecilia Lo
MGI ID: MGI:5646612
Synonyms: Po
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 3077-006-2 (E15.5) exhibits parallel outflow tracts, pulmonary stenosis, and small left atrium later diagnosed as double outlet right ventricle (DORV), hypoplastic pulmonary artery, and hypoplastic left atrium by ECM histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D ECM image stack of 3077-006-2 (E15.5) in the coronal plane reveals double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), common atrium, hypoplastic pulmonary artery (PA), hypoplastic left atrium, and ventricular myocardial non-compaction.
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Color flow spectral Doppler imaging of mutant 3077-006-2 (E15.5) in the sagittal view shows only aorta overriding over septum, suggesting double outlet right ventricle (DORV) with pulmonary stenosis (PS) or pulmonary atresia.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) presents with hydrops, petechiae, short snout, micrognathia, short limbs, syndactyly, clubbed feet, and short tail.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) shows a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) presents with a cleft palate.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) exhibits a short gut.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) has an abnormal placement of the gonads and abnormal kidneys, later confirmed as duplex kidney with some glomerular cysts by histologyb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-2 (E15.5) exhibits duplex kidney with some glomerular cysts.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-3 (E15.5) exhibits a large, single outflow which was later diagnosed as persistent truncus arteriosis (PTA) by ECM histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D image stack of 3077-006-3 (E15.5) in the coronal plane reveals persistent truncus arteriosis (PTA) (Type 1).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Color flow spectral doppler imaging of 3077-006-3 (E15.5) in the sagittal view shows only one great artery originating from the heart indicating persistent truncus arteriosis (PTA).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-3 (E15.5) shows hydrops, petechiae, short snout, micrognathia, short limbs, clubbed feet, syndactuly, and short tail.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-3 (E15.5) exhibits a short gut.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-3 (E15.5) only has a right thymus gland which is extremely hypoplastic.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) shows a small left ventricle and a single outflow tract, later diagnosed as persistent truncus arteriosis (PTA) type 1 by ECM histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D ECM image stack of 3077-006-1 (E15.5) in the coronal plane reveals persistent truncus arteriosis (PTA Type 1), atrioventricular septal defect (AVSD), and small left ventricle (LV).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) has syndactyly, short limbs, is runted, micrognathia, a short snout, a short tail, underdeveloped ear pinna, and low-set ears.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) presents with a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) shows a cleft palate.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) has hypoplastic thymusb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) exhibits hypoplastic lungs.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-1 (E15.5) presents with a short gutb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits only one outflow tract which is diagnosed by ECM imaging as persistent truncus arterioris (PTA) type II and small left ventricleb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D ECM image stack of 3077-002-2 (ED14.5) in the coronal plane reveals persistent truncus arteriosis (Type II) with atrioventricular septal defect (AVSD), and small left ventricle (LV).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits abnormal thymuses.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits abnormally shaped kidneys which is diagnosed as bilateral duplex kidney with glomerular cysts by histopathologyb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) has bilateral duplex kidney with glomerular cysts.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-2 (E14.5) exhibits short snout, micrognathia, hydrops, low-set ears, and clubbed handsb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-1 (E14.5) displays only one outflow tract which is diagnosed as persistent truncus arteriosis (PTA) type 1 and small left ventricle by ECM imagingb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Serial 2D ECM image stack of 3077-002-1 (ED14.5) in the coronal plane reveals persistent truncus arteriosis (type I), atrioventricular septal defect (AVSD), and small left ventricular (LV).
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-1 (E14.5) presents with micrognathia, short snout, hydrops, no tail, clubbed limbs, petechiae, and low-set earsb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-1 (E14.5) exhibits a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-002-1 (E14.5) shows a cleft palateb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
Wnt5ab2b3077.1Clo/Wnt5ab2b3077.1CloC57BL/6J-Wnt5ab2b3077.1Clo
Mutant 3077-006-4 (E15.5) exhibits aortic atresia with accessory anterior lung lobes, hypoplastic left atrium, and thickened left ventricle wall. This is diagnosed as aortic atresia, left venricle hypertrophy, and hypoplastic left heart syndrome (HLHS) spectrum heart by ECM histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
EFIC Summaryb2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Serial 2D ECM image stack of 3077-006-4 (E15.5) in the coronal plane reveals hypoplastic left heart syndrome with aortic atresia, mitral valve stenosis, and muscle bound hypoplastic left ventricle. Also noted was abnormal acccessory anterior lung lobes.
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
3D ECM reconstruction of 3077-006-4 shows accessory anterior lung lobes positioned above the atria.
Click thumbnail to play movie.		b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) presents with hydrops, short snout, micrognathia, short limbs, clubbed feet, syndactyly, and short tail.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) presents with a cleft lip.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) exhibits a cleft palate.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) shows a short gut.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) exhibits abnormally placed adrenal glands and cystic kidneys, later confirmed showing a few glomerular cysts by histopathology.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
Mutant 3077-006-4 (E15.5) shows some glomerular cysts.b2b3077Clo/b2b3077CloC57BL/6J-b2b3077Clo
b2b3077.2Clo/b2b3077.2CloC57BL/6J-b2b3077.2Clo
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory