Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Dvl3^b2b2866Clo
Name:	dishevelled segment polarity protein 3; Bench to Bassinet Program (B2B/CVDC), mutation 2866 Cecilia Lo
MGI ID:	MGI:5618437

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Mutant (E14.5) presents with malaligned outflow tracts, later diagnosed as double outlet right ventricle (DORV) by ECM histopathology.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	EFIC Summary	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Serial 2D ECM image stack in the coronal plane of mutant (E14.5) reveals double outlet right ventricle (DORV), subaortic VSD, and cushion-like semilunar valves Click thumbnail to play movie.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant (E14.5) shows a hypoplastic thymus.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant (E14.5) presents with a short snout and micrognathia.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant (E14.5) presents with malpositioned pulmonary artery (PA), later diagnosed as double outlet right ventricle by ECM histopathology.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Color flow spectral Doppler imaging of mutant (E14.5) in the sagittal view shows two great arteries originating from the right ventricle (RV) primarily with pulmonary artery (PA) insufficiency, a shunt between the left and right ventricle beneath the aorta, suggesting double outlet right ventricle (DORV). Click thumbnail to play movie.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	EFIC Summary	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Serial 2D ECM image stack in the coronal plane of mutant (E14.5) reveals double outlet right ventricle (DORV) and subaortic VSD. Click thumbnail to play movie.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant (E14.5) presents with a short snout and micrognathia.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant (E14.5) exhibit hypoplastic thymus.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant (E14.5) exhibit kidneys with hydronephrosis.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant 2866-003-2 at E14.5 shows hydrophrosis and moderate cystic kidney disease.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant 2866-003-2 at E14.5 shows hydrophrosis and moderate cystic kidney disease.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant 2866-003-2 at E14.5 appear to have abnormal cystic kidney with possible hydronephrosis which was confirmed by histology.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo
	Mutant 2866-003-3 at E14.5 shows hydrophrosis and moderate cystic kidney disease.	Dvl3^b2b2866Clo/Dvl3^b2b2866Clo	C57BL/6J-Dvl3^b2b2866Clo

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