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Phenotype Images associated with this Allele
Nomenclature
Symbol: Foxh1b2b2662Clo
Name: forkhead box H1; Bench to Bassinet Program (B2B/CVDC), mutation 2662 Cecilia Lo
MGI ID: MGI:5615244
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant exhibits displaced outflow tracts which is diagnosed as double outlet single ventricle, right aortic arch, and aberrant right subclavian artery forming incomplete vascular ring by ECM imagingFoxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
EFIC SummaryFoxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Serial 2D ECM image stack of mutant in the coronal plane reveals double outlet single ventricle. {A,A(D),D} , right aortic arch, unbalanced atrioventricluar septal defect, common atrium, RAI, aberrant right subclavian artery forming incomplete vascular ring, and right lung isomerism
Click thumbnail to play movie.		Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant presents with severe craniofacial defects including cyclopia, agnathia with proboscis, and low-set ears.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant 2662-004-NA exhibits right lung isomerism (4 lobes on each side).Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant exhibits heterotaxy with levocardia, left aortic arch, right lung isomerism (3 lobes on each side), dextrogastria, and Taussig-Bing type double outlet right ventricle (DORV) that was diagnosed by ECM histopathology.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
EFIC SummaryFoxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Serial 2D ECM image stack of mutant in the coronal plane reveals Taussig Bing type double outlet right ventricle {A,D,D}, atrioventricular septal defect (AVSD), common atrium, and right lung isomerism.
Click thumbnail to play movie.		Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant exhibits heterotaxy with mesocardia, right lung isomerism (3 lobes on each side), Taussig-Bing type double outlet right ventricle (DORV), hypoplastic left ventricle, right aortic arch, and dual inferior vena cava, which are all diagnosed by ECM imaging.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
EFIC SummaryFoxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Serial 2D ECM image stack of mutant in the coronal plane reveals mesocardia {A,L,L}, Taussig Bing double outlet right ventricle, unbalanced atrioventricular septal defect, common atrium, hypoplastic LV, RAA, right inferior vena cava and left hepatic vein connecting to atrium, and right lung isomerism
Click thumbnail to play movie.		Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Serial 2D ECM image stack of mutant in the coronal plane of whole body reveals right diaphragmatic hernia. mesocardia, (A,L,L), Taussig Bing DORV, unbalanced AVSD, common atrium, hypoplatic LV, RAA, right IVC and left hepatic vein connect to atrium, right lung isomerism.
Click thumbnail to play movie.		Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant presents with malaligned sternum.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant shows severe craniofacial defects with anencephaly, acrania, agnathia, and anopthalmia.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant exhibits microstomia with skin tags that may be abnormally positioned pinnae.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant exhibits right diaphragmatic hernia with stomach in the thoracic cavity, and also seen is intestinal malrotation.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
EFIC SummaryFoxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Serial 2D ECM image stack of mutant in the coronal plane reveals Taussig-Bing type DORV {A,D,D}, RAA, unbalanced AVSD, common atrium, hypoplastic LV, and right lung isomerism
Click thumbnail to play movie.		Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Serial micro-MRI image stack of mutant in the coronal plane reveals double outlet right ventricle (DORV), unbalanced atrioventricular septal defect (AVSD), hypoplastic LV. Bilateral anophthamial, craniofacial hypoplasia, microcephaly, micrognathia or agnathia.
Click thumbnail to play movie.		Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant (E14.5) exhibits heterotaxy with dextrocardia.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant (E14.5) shows heterotaxy with dextrocardia and anterior placement of the aorta, suggesting outflow tract malalignment defects.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Mutant (E14.5) presents with severe craniofacial defects including anencephaly, agnathia, anopthalmia, low-set ears, acrania, phenotypes consistent with otocephaly.Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
EFIC SummaryFoxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Serial 2D ECM image stack of mutant (ED14.5) in the coronal plane reveals heterotaxy, dextrocardia, Taussig Bing type double outlet right ventricle (DORV), unbalanced atrioventricular septal defect, common atrium, IVC connected at the middle of the atrium {A,L,L}, TAPVR (to right SVC), aberrant right aortic arch and pulmonary arch anomalies forming incomplete vascular ring, aberrant semilunar valve formation (cushion like), and right lung isomerism.
Click thumbnail to play movie.		Foxh1b2b2662Clo/Foxh1b2b2662CloC57BL/6J-Foxh1b2b2662Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory