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Phenotype Images associated with this Allele
Nomenclature
Symbol: Twf2b2b2576Clo
Name: twinfilin actin binding protein 2; Bench to Bassinet Program (B2B/CVDC), mutation 2576 Cecilia Lo
MGI ID: MGI:5615000
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant (E14.5) presents with hypoplastic thymus on the left and right thymus ageneis
Mutant (E14.5) exhibits midline facial cleft and apparent single outflow tract, confirmed as persistent truncus arteriosus by ECM histopathology.
EFIC Summary
Serial 2D ECM image stack of 2576-002-1 (ED14.5) in the coronal plane reveals persistent truncus arteriosus (PTA-type 1), atrioventricular septal defect (AVSD), right aberrant subclavian artery.
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Mutant (E14.5) is runted with hydrops and exhibits craniofacial defects including micrognathia, short snout, and micropthalmia of the right eye
Mutant (E14.5) exhibits midline facial cleft and severe hydrops
EFIC Summary
Serial 2D ECM stack of mutant (ED14.5) in the coronal plane reveals double outlet right ventricle (DORV), subaortic ventricular septal defect (VSD) and biventricular hypertrophy.
Click thumbnail to play movie.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory