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Phenotype Images associated with this Allele
Nomenclature
Symbol: Tll1b2b2476Clo
Name: tolloid-like; Bench to Bassinet Program (B2B/CVDC), mutation 2476 Cecilia Lo
MGI ID: MGI:5560905
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2476-007-1 (E16.5) is developmentally delayed, exhibits parallel outflow tracts and thin ventricle walls which is diagnosed as DORV and ventricular non-compaction by EFIC imagingTll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
EFIC SummaryTll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
Serial 2D EFIC image stack in the coronal plane of 2476-007-1 (E16.5) shows DORV, subaortic VSD, mVSD, and ventricular myocardial non-compaction
Click thumbnail to play movie.
Tll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
Mutant 2476-007-1 (E16.5) presents with a palate that is not completely fusedTll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
Mutant 2476-007-3 (E16.5) shows parallel outflow tracts and thin ventricular walls which is confirmed as DORV and ventricular non-compaction by EFIC imagingTll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
EFIC SummaryTll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
Serial 2D EFIC image stack in the coronal plane of 2476-007-3 (E16.5) shows DORV, subaortic VSD, mVSD, and ventricular noncompaction
Click thumbnail to play movie.
Tll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
Mutant 2476-007-2 (E16.5) is developmentally delayed and exhibits abnormal placement of the great arteries and RAA. Diagnosis by EFIC imaging is overriding aorta, RAA, incomplete vascular ring, and ventricular non-compactionTll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
EFIC SummaryTll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
Serial 2D EFIC image stack in the coronal plane of 2476-007-2 (E16.5) shows overriding aorta, pmVSD, RAA, aberrant left subclavian artery forming incomplete vascular ring, and ventricular non-compaction
Click thumbnail to play movie.
Tll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
Mutant 2476-007-2 (E16.5) shows a palate that has not completely fusedTll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo
Mutant 2476-007-2 (E16.5) has hypoplastic thymusTll1b2b2476Clo/Tll1b2b2476CloC57BL/6J-Tll1b2b2476Clo

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory