Phenotype Images associated with this Allele
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Nomenclature
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Symbol:
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b2b2459Clo
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Name:
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Mutant line 2459;
Bench to Bassinet Program (B2B/CVDC), mutation 2459 Cecilia Lo
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MGI ID:
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MGI:5560903
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Images for
Allele
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Click images for details
 | Mutant 2459-006-1 (E16.5) exhibits malalignment of the great arteries, shown to be double outlet right ventricle (DORV) by EFIC imaging | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | EFIC Summary | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Serial 2D EFIC image stack in the coronal plane of 2459-006-1 (E16.5) shows DORV, AVSD, RV non-compaction, LV hypertrophy, and cushion-like valves
Click thumbnail to play movie. | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Mutant 2459-006-1 (E16.5) presents with hydrops and ptechiae | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Mutant 2459-006-1 (E16.5) shows kidneys that appear cystic and have hydronephrosis | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Mutant 2459-006-1 has moderately cystic kidneys | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Mutant 2459-003-2 (E14.5) shows cystic and dysplastic kidneys | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | EFIC Summary | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Serial 2D EFIC image stack in the coronal plane of 2459-003-2 (E14.5) shows DORV, subaortic VSD, and dysplastic aortic valve
Click thumbnail to play movie. | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Color flow spectral Doppler imaging of mutant 2459-003-1 (E14.5) in the sagittal view shows both great arteries originating from the RV predominantly with sub aortic VSD, indicating DORV.
Click thumbnail to play | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Mutant 2459-003-2 (E14.5) was harvested with hydrops and abnormal vasculature | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Mutant 2459-003-2 (E14.5) presents with hypoplastic thymus | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Mutant 2459-003-1 (E14.5) is developmentally delayed. Outflow is slightly malrotated which is confirmed to be DORV and ventricular non-compaction by EFIC imaging | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | EFIC Summary | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Serial 2D EFIC image stack in the coronal plane of 2459-003-1 (E14.5) shows developmental delay, DORV, subaortic VSD, cushion-like valves, and ventricular non-compaction
Click thumbnail to play movie. | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Mutant 2459-007-NA exhibits hypoplastic transverse aorta and abnormal positioning of the great arteries which is diagnosed as DORV by EFIC imaging | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | EFIC Summary | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Serial 2D EFIC image stack in the coronal plane of 2459-007-NA shows DORV, subaortic VSD, and hypoplastic transverse aorta
Click thumbnail to play movie. | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
 | Serial micro-MRI image stack of 2459-007-NA in the coronal plane reveals DORV and subaortic VSD
Click thumbnail to play movie. | b2b2459Clo/b2b2459Clo | C57BL/6J-b2b2459Clo |
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