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Phenotype Images associated with this Allele
Nomenclature
Symbol: Adamts6b2b2407Clo
Name: ADAM metallopeptidase with thrombospondin type 1 motif 6; Bench to Bassinet Program (B2B/CVDC), mutation 2407 Cecilia Lo
MGI ID: MGI:5560143
Synonyms: Rory
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Mutant 2407-003-4 (E16.5) exhibits malalignment of the great arteries, which is confirmed by EFIC imaging as overridng aorta, a hypoplastic transverse arch and possible ventricular non-compactionAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
EFIC SummaryAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Serial 2D EFIC image stack in the coronal plane of 2407-003-4 (E16.5) reveals overriding aorta, pmVSD, and ventricular non-compaction suspected
Click thumbnail to play movie.		Adamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-4 (E16.5) presents with a short snout, abnormally attached hindlimbs, and slight hydropsAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-4 (E16.5) exhibits a cleft palateAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-4 (E16.5) presents with an unfused sternumAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-4 (E16.5) shows hypoplastic thymusAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Color flow Doppler imaging in the sagittal view of mutant 2407-003-4 (E16.5) shows a VSD and both great arteries originating from RV with aliasing in Ao, which suggests DORVAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Color flow Doppler imaging in the sagittal view of mutant 2407-003-4 (E16.5) shows a VSD and both great arteries originating from RV with regurgitation of Ao and PA, which suggests DORVAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Spectral Doppler imaging of mutant 2407-003-4 (E16.5) confirms that the aliasing in Ao is aortic stenosis with regurgitationAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Color flow Doppler imaging in the transverse view of mutant 2407-003-4 (E16.5) shows a VSDAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-3 (E16.5) exhibits a short snout and abnormally attached hindlimbsAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-3 (E16.5) has a cleft palateAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-3 (E16.5) shows malalignment of the great arteries, which is diagnosed as overriding aorta by EFIC imagingAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
EFIC SummaryAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Serial 2D EFIC image stack in the coronal plane of 2407-003-3 (E16.5) reveals overriding aorta, pmVSD, and ventricular non-compaction suspected
Click thumbnail to play movie.		Adamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Color flow spectral Doppler imaging of mutant 2407-003-3 (E16.5) in the sagittal view shows aorta overriding over septum
Click thumbnail to play movie.		Adamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-1 (E16.5) presents with a cleft palateAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-1 (E16.5) has a hypoplastic thymusAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-003-1 (E16.5) is diagnosed with DORV and hypoplastic PA by EFIC imagingAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
EFIC SummaryAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Serial 2D EFIC image stack in the coronal plane of 2407-003-1 (E16.5) shows DORV, AVSD, hypoplastic PA, and ventricular non-compaction
Click thumbnail to play movie.		Adamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-005-NB exhibits abnormally attached hindlimbs, short snout, and micrognathiaAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-005-NB shows an unfused sternumAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Mutant 2407-005-NB has parallel outflow tracts which is diagnosed as overriding aorta by EFIC imagingAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
EFIC SummaryAdamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Serial 2D EFIC image stack of 2407-005-NB in the coronal plane reveals an overriding aorta and pmVSD
Click thumbnail to play movie.		Adamts6b2b2407Clo/Adamts6b2b2407CloC57BL/6J-Adamts6b2b2407Clo
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory